Biomedicines
Dual Inhibition of the Renin-Angiotensin-Aldosterone System and Sodium-Glucose Cotransporter-2: Mechanistic and Clinical Evidence for Cardiorenal Protection.
Reem F M Aazar, Rayan Arzouni, Persoulla A Nicolaou
Published: 202610.3390/biomedicines14010101
Abstract
Overactivation of the renin-angiotensin-aldosterone system (RAAS) promotes haemodynamic overload, inflammation, and fibrosis in the heart and kidneys. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a cornerstone therapy i…
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