Biomedicines
The TRPV1 Channel Modulator Imidazo[1,2-a]Indole Derivative Exhibits Pronounced and Versatile Anti-Inflammatory Activity In Vivo.
Pavel A Galenko-Yaroshevsky, Anait V Zelenskaya, Konstantin F Suzdalev, Tatyana N Popova, Aleksandra N Kvetkina, Margarita M Shamatova, Elena N Chuyan, Marina Yu Ravaeva, Roman A Murashko, Tereza R Glechyan, Alina V Sergeeva, Narek N Ishkhanyan, Olga N Gulevskaya, Vladislav I Chubinskiy-Nadezhdin, Evgenii D Kryl'skii
Published: 202510.3390/biomedicines14010060
Abstract
Background: Recently, data have been published about the inhibitory effect at low nanomolar concentrations on the TRPV1 ion channel for a new indole derivative named SV-1010. This molecule has also been shown to have a strong analgesic effect in mice…
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