BiomoleculesHumansIntervertebral DiscLactic AcidIntervertebral Disc DegenerationAnimals
Lactate Metabolism in the Intervertebral Disc: Mechanistic Insights and Pathological Implications.
Ting Zhang, Peng Feng, Peter G Alexander, Joon Y Lee, Gwendolyn A Sowa, Nam V Vo
Published: 202610.3390/biom16010170
Abstract
The intervertebral disc (IVD) is the largest avascular structure in the human body, and its nucleus pulposus (NP) cells predominantly generate large amounts of lactate through glycolysis, accompanied by an acidic microenvironment-features that repres…
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