Biomoleculesalpha 1-AntitrypsinAnimalsHumansMelanomaMice
Human Alpha-1 Antitrypsin Suppresses Melanoma Growth by Promoting Tumor Differentiation and CD8+ T-Cell-Mediated Immunity.
Takeshi Yamauchi, Yuchun Luo, Dinoop Ravindran Menon, Kasey Couts, Sana Khan, Aanchal Goel, Charles A Dinarello, Zili Zhai, Mayumi Fujita
Published: 202610.3390/biom16010122
Abstract
Alpha-1 antitrypsin (AAT) is a serine protease inhibitor with potent anti-inflammatory and immunomodulatory properties, but its role in cancer is context-dependent across tumor types. We integrated transcriptomic analyses of human melanoma cohorts, i…
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