Antioxidants (Basel, Switzerland)
Olive Leaf Extract Added to Losartan Treatment Improved Klotho/Wnt/β-Catenin Signaling in Hypertensive Rats with Focal Segmental Glomerulosclerosis.
Danijela Karanović, Nevena Mihailović-Stanojević, Milan Ivanov, Una-Jovana Vujačić, Jelica Grujić-Milanović, Maja Životić, Dragana Dekanski, Djurdjica Jovović, Zoran Miloradović
Published: 202610.3390/antiox15010146
Abstract
The downregulation of Klotho in renal injury predicts the progression of chronic kidney disease (CKD). Klotho acts as an antagonist of the Wnt/β-catenin pathway, which is involved in the pathogenesis of proteinuria, glomerulosclerosis and tubulointer…
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