Frontiers in oncology
Functional pancreatic neuroendocrine tumors predominantly presenting with hypercalcemia: a case report.
Jieting Duan, Yanping Zhu, Yan Wang, Xiang Kui, Yingmei Tang
Published: 202510.3389/fonc.2025.1693096
Abstract
Open AccessFunctional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumor (PNET) and recurrent life-threatening hypercalcemia. Moreover, it comprehensively describes the evolution and management of hypercalcemia in this case, aiming to offer valuable insights for clinical diagnosis and treatment.