Connectome-based predictive modeling of grip strength: a marker of physical frailty.

Introduction: Frailty is characterized by a persistent and progressive decline in functional capacity, leading to increased vulnerability to stressors and a heightened risk of adverse health outcomes, both physically and mentally. Despite frailty's prevalence in older adults, there is limited research on its neural substrates. Methods: In this study, we used connectome-based predictive modeling (CPM) to find a linear relationship between task-based connectomes taken from tasks that involved similar handgrip manipulations and a separate measure of physical frailty: the maximum grip strength in older adults. Results: We observed that the task-based connectomes were able to explain individual differences in grip strength, with the Subcortical and Cerebellum network, particularly the caudate nucleus functional connectivity, being the strongest predictor. Discussion: These findings demonstrate that task-based functional connectomes can serve as personalized markers for predicting individual behavioral measures, such as handgrip strength, and highlight the role of the caudate nucleus in physical frailty.