Heart disease prediction with a feature-sensitized interpretable framework for the Internet of Medical Things sensors.

Introduction: Cardiovascular health is increasingly at risk due to modern lifestyle factors such as obesity, smoking, stress, hypertension, and sedentary behavior. Post-pandemic health practices and medication side effects have further contributed to rising cases of early heart failure, particularly among individuals aged 25-40 years. This highlights the need for an automated and interpretable framework to predict heart disease at an early stage. Methods: In this study, body vitals acquired from a secondary dataset. Machine learning models including Support Vector Machine, Random Forest, Decision Tree, and Logistic Regression were employed for classification. Model performance was evaluated using accuracy, F1-score, and k-fold cross-validation. Results: Among the tested models, the Random Forest classifier demonstrated superior performance with an accuracy and F1-score of 0.955. The interpretability is enhanced with model predictions were explained using Local Interpretable Model-Agnostic Explanations (LIME) for local surrogates and SHAP values for global surrogates. SHAP decision plots provided clear insights into classification behaviour and feature contributions. Discussion/Conclusion: The proposed interpretable machine learning framework successfully predicts heart disease with high accuracy while maintaining transparency in decision-making. With the integration of sensor data with cloud-based analysis and explainable AI techniques, this study contributes to reducing the incidence of early heart failures and supports more reliable decision-making in healthcare applications.