Haematologica
Protein phosphatase 2A orchestrates hematopoietic fate determination via modulation of lactate metabolism.
Can Liu, Yao Meng, Heng Chen, Siqi Bi, Ye Tian, Zhihua Yin, Guanhua Li, Wutao Chen, Li Wu, You Wang, Nan Shen, Haibo Zhou
Published: 202510.3324/haematol.2025.288868
Abstract
Abnormal hematopoiesis is inherently linked to metabolic reprogramming. Protein phosphatase 2A (PP2A), a master regulator of hematopoietic homeostasis, has been implicated in multiple hematological disorders. However, the precise mechanisms by which…
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