Haematologica
TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.
Lei Zhang, Wenyan Li, Rohit Thalla, Rongyao Ma, Ryan Mack, Ameet R Kini, Austin Runde, Patrick A Hagen, Kevin Barton, Jorgena Kosti-Schwartz, Peter Breslin, Hong-Long Ji, Jiwang Zhang
Published: 202510.3324/haematol.2025.287951
Abstract
Mutant SF3B1 (SF3B1mut) in hematopoietic stem/progenitor cells (HSPCs) primarily affects erythropoiesis, resulting in myelodysplastic syndromes (MDS) with refractory macrocytic anemia and ring sideroblasts. SF3B1mut results in aberrant splicing of a…
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