Molekuliarnaia biologiiaHistone Deacetylase InhibitorsHumansHistone DeacetylasesHydroxamic AcidsZinc
[Zinc-Dependent Histone Deacetylase (HDAC) Inhibitors: Therapeutic Potential, Pharmacophore Structure, and Methods for Testing Deacylase Activity].
A S Zemskaya, S N Kochetkov, M V Kozlov
Published: 202510.31857/S0026898425050021
Abstract
In 1976, the antifungal hydroxamic antibiotic trichostatin A (TSA) was isolated from the metabolites of the bacterium Streptomyces hygroscopicus. It took 14 years to find that TSA has an effect on the proliferation and differentiation of mammalian ce…
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