Frontiers in bioscience (Landmark edition)HumansCamptothecinAutophagyImmunoconjugatesAntibodies
Interrogating the Involvement of Autophagy, Senescence, and the Immune System in the Actions of Sacituzumab Govitecan as an Anticancer Agent.
Melanie M Sinanian, Eesha Chakraborty, Ahmed M Elshazly, Shady Azzam, Nada Nassif, David A Gewirtz
Published: 202510.31083/FBL39310
Abstract
Antibody-drug conjugates (ADCs) are an emerging class of cancer therapeutics comprised of a tumor-targeting antibody linked to a cytotoxic payload. Sacituzumab govitecan (SG or IMMU-132) is comprised of a trophoblast cell-surface antigen 2 (TROP-2)-d…
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