Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Immunotheranostics in Solid Tumors: Longitudinal Tracking of Human IL13Rα2 CAR-T Cells In Vivo.
Hamid Reza Mirzaei, Samantha Lovibond, Leah Gajecki, Sarah Qureshy, Melina Kumpf, Pauline Jeanjean, Sang Gyu Lee, Winson Cai, Ileana Miranda, Audrey Mauguen, Lukas M Carter, Heiko Schöder, Darren R Veach, David A Scheinberg, Simone Krebs
Published: 202510.2967/jnumed.125.271365
Abstract
Chimeric antigen receptor (CAR)-T cell therapy has shown limited success in the treatment of solid tumors, reinforcing the need to elucidate the in vivo biodistribution of these engineered T cells. Here, we integrate the anti-DOTA huC825 reporter ("T…
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