Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Phase 1 Study of [177Lu]Lu-NeoB in Patients with Advanced Solid Tumors Overexpressing Gastrin-Releasing Peptide Receptor: Preliminary Safety and Dosimetry Results.
Erik S Mittra, Lilja B Solnes, Astrid A M van der Veldt, Jeffrey Wong, Luigi Aloj, Michael C Heinrich, Christopher T Chen, Steven P Rowe, Tessa Brabander, Simon Pacey, Paola Aimone, Dhrubajyoti Pathak, Lars Blumenstein, Yongmin Liu, Andrei Iagaru
Published: 202510.2967/jnumed.125.270411
Abstract
Gastrin-releasing peptide receptor (GRPR) is overexpressed in a range of tumor types, making it an attractive candidate for novel treatment approaches. NeoB binds to GRPR with high affinity and can be radiolabeled with 68Ga ([68Ga]Ga-NeoB) for imagin…
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