Zoological researchAnimalsRetinal Cone Photoreceptor CellsMiceRatsMosaicism
ARR3 variant-induced cone mosaicism alters cone subtype composition and disrupts phototransduction.
Jiamin Ouyang, Zhen Yi, Yi Jiang, Xueqing Li, Gongpei Wang, Yingwei Wang, Wenting Du, Shuowei Chen, Yijun Dong, Xueshan Xiao, J Fielding Hejtmancik, Wenmin Sun, Qingjiong Zhang
Published: 202610.24272/j.issn.2095-8137.2025.103
Abstract
Heterozygous variants in ARR3, encoding cone arrestin, have emerged as a frequent cause of early-onset high myopia with a unique X-linked female-limited inheritance pattern. However, the mechanistic basis for this unusual anti-X-linked pattern is sti…
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