Diabetes care
Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial.
Anette-Gabriele Ziegler, Ali Albeer, Stefanie Arnolds, Robin Assfalg, Melanie Bunk, Carolin Daniel, Anna Hofelich, Stefanie Jacobsen, Kerstin Kick, Jan Knoop, Mirjam Kohls, Olga Kordonouri, Claudia Matzke, Markus Pfirrmann, Claudia Ramminger
Published: 202610.2337/dc25-2818
Abstract
OBJECTIVE: Oral administration of an antigen can induce immunological tolerance. Insulin is an autoantigen in childhood type 1 diabetes (T1D). We tested the effect of treatment with high-dose oral insulin on disease progression and immune response to…
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