DiabetesAnimalsHypoglycemiaMiceProstaglandinsHypothalamus
Hypothalamic Prostaglandins Facilitate Recovery From Severe Hypoglycemia but Exacerbate Recurrent Hypoglycemia in Mice.
Takashi Abe, Shucheng Xu, Yuki Sugiura, Yuichiro Arima, Takahiro Hayasaka, Ming-Liang Lee, Taiga Ishimoto, Yudai Araki, Samson Ngurari, Ziwei Niu, Norifumi Iijima, Sabrina Diano, Chitoku Toda
Published: 202510.2337/db25-0106
Abstract
The hypothalamus monitors blood glucose levels and regulates glucose production in the liver. In response to hypoglycemia, glucose-inhibited (GI) neurons trigger counterregulatory responses (CRRs), which stimulate the release of glucagon, epinephrine…
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