JMIR research protocols
Flopropione, a cysteine-conjugate-β-lyase 1 inhibitor, for prevention of cisplatin-induced nephrotoxicity: protocol for a randomized, open-label, proof-of-concept phase I/IIa trial.
Takenao Koseki, Masashi Kondo, Hidetsugu Fujigaki, Kayoko Kikuchi, Yuko Oya, Hiroshi Kato, Tomohiro Mizuno, Naotake Tsuboi, Kenji Kawada, Yasuhiro Goto, Naozumi Hashimoto, Kazuyoshi Imaizumi, Akiko Kada, Hikaru Yabuuchi, Kuniaki Saito
Published: 202610.2196/87907
Abstract
BACKGROUND: Cisplatin-induced nephrotoxicity (CIN) is a major dose-limiting adverse event that can lead to both acute and chronic kidney injury. The formation of thiol-cisplatin conjugates within renal tubular cells has been implicated as a key mecha…
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