Anticancer researchHumansChloroquinePancreatic NeoplasmsFibroblastsSirolimus
Simultaneous Targeting of Multiple Hallmarks of Cancer With Recombinant Methioninase, Rapamycin and Chloroquine Is Specific and Synergistic to MiaPaCa-2 Pancreatic-Cancer Cells in Contrast to Hs-27 Normal Fibroblasts.
Jinsoo Kim, Qinghong Han, Shukuan Li, Byung Mo Kang, Kohei Mizuta, Yohei Asano, Yuta Miyashi, Michael Bouvet, Robert M Hoffman
Published: 202510.21873/anticanres.17825
Abstract
BACKGROUND/AIM: Pancreatic ductal adenocarcinoma (PDAC) is recalcitrant to conventional therapies. Recombinant methioninase (rMETase), rapamycin, and chloroquine target fundamental hallmarks of cancer. The present study examined the efficacy of each…
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