Drug metabolism and bioanalysis lettersHydrolysisAnimalsHumansCoumarinsGlucuronides
`3-Hydroxy-6H,7H-chromeno [3,4-c]chromene-6,7-dione as a Substrate for Studying Glucuronidation, Sulfonation and Lactone Hydrolysis.
Risto O Juvonen, Tuomo Laitinen, Joana David, Margarida Ferreira, Jasmin Etemadi, Oussama Mekhalia, Ina Onatsu, Emma Pätsi, Juhani Huuskonen, Moshe Finel, Hannu Raunio, Veera Lassheikki, Aki T Heikkinen, Seppo Auriola
Published: 202510.2174/0118723128351379250312063255
Abstract
INTRODUCTION/OBJECTIVE: Glucuronidation and sulfonation enzymes conjugate compounds containing a hydroxyl group, while paraoxonase enzymes hydrolyze lactonecontaining compounds. 3-Hydroxy-6H,7H-chromeno [3,4-c]chromene-6,7-dione (3- hydroxy-V-coumari…
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