Endocrine, metabolic & immune disorders drug targets
17β-Estradiol Improves Liver Function in T2DMNAFLD Mice via PGC-1α/ERRα Axis Activation While Preserving Cholestatic Safety.
Wangwei Xu, Qiaoyun Ni, Qingqing Yang, Qisi Lin
Published: 202510.2174/0118715303434124251112064139
Abstract
INTRODUCTION: This study investigated the hepatoprotective effects and mechanisms of 17β-estradiol (E2) in a mouse model of type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). METHODS: Male C57BL/6J mice (n = 6/group) were…
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