Anti-cancer agents in medicinal chemistry
Discovery of Small Molecule Inhibitors against Polo-Like Kinase 1 Targeting Breast Cancer.
Gayatri Munieswaran, Venkatraman Manickam
Published: 202610.2174/0118715206423642251022100027
Abstract
INTRODUCTION: The polo-like kinase-1 (PLK1) plays a significant role in cell cycle regulation and proliferation; upon dysregulation, PLK1 activates different oncogenic pathways that lead to breast cancer. Therefore, targeting the PLK1 protein on the…
Preview only. Read the full abstract at the source