Recent patents on anti-cancer drug discovery
Histone Deacetylases as Epigenetic Regulators of EMT in Hypoxia-driven Tumor Metastasis: Mechanistic Insights and Therapeutic Implications.
Yin Bao, Jun Zhu, Hong Zhu, Jun Gao
Published: 202610.2174/0115748928416410251128094143
Abstract
INTRODUCTION: The hypoxic microenvironment is a hallmark of solid tumors, driving metastasis through Hypoxia-Inducible Factor-1α (HIF-1α)-mediated Epithelial-Mesenchymal Transition (EMT). Histone deacetylases (HDACs) critically enhance HIF-1α signali…
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