Current organic synthesisSulfonamidesIsoquinolinesDrug ContaminationMolecular StructureUrea
Unveiling New Process Impurities in Ripasudil Hydrochloride Dihydrate: Identification, Synthesis, and Characterization.
Kedarnath M Birajdar, Sudhakar Arrahalli, Praveen Beekanhalli Mokshanatha, Prashanth Kumar Babu
Published: 202510.2174/0115701794347179250123101111
Abstract
BACKGROUND: Ripasudil hydrochloride or 4-Fluoro-5-{[(2S)-2-Methyl-1,4- diazepan-1-yl] sulfonyl isoquinoline hydrochloride known as K-115 is used for the treatment of glaucoma and ocular hypertension. In the API industry, to achieve and ensure the qua…
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