Current topics in medicinal chemistry
Designing Novel NMDA Receptor Antagonists for Ischemic Stroke: A 3D-QSAR and Molecular Dynamics Simulation Approach.
Zhuangzhuang Wan, Xiaolin Jiang, Chenlon Fan, Boru Hou
Published: 202510.2174/0115680266412043251124065339
Abstract
BACKGROUND: Strokes represent a significant global health concern, with ischemic stroke being the most prevalent and deadly form. The pathogenesis of ischemic stroke involves complex mechanisms, including excitotoxicity, oxidative stress, and cell de…
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