Current drug metabolism
TOX4 Inhibition in Chronic Hyperglycemia: Effects on Glycation Stress, Hepatic Protection, Epigenetic Mechanisms, Signaling Pathways, and Beta Cell Dynamics.
Bonthu Varunteja, Nayan Gupta, Anjali Kumari, Tuhin Mukherjee, Satyajit Mohanty, Nikita Nayak, Mahendra Pratap Chopra, Ashok Pattnaik
Published: 202510.2174/0113892002393234250908070423
Abstract
TOX high mobility group box family member 4 (TOX4) has emerged as a critical regulator of Hepatic Glucose Production (HGP), particularly under insulin-resistant condi-tions seen in Type 2 Diabetes Mellitus (T2DM). Hyperglycemia-induced formation of A…
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