Combinatorial chemistry & high throughput screening
Impact of All-trans Retinoic Acid on Skeletal Development: Mechanisms of Growth Plate Closure.
Fan Xuan, Yutong Xing, Zuyan Mei, Yanan Zhang, YaLei Pi, Xiaoli Wu, Huifeng Zhang
Published: 202510.2174/0113862073424590251103061707
Abstract
INTRODUCTION: All-trans retinoic acid (ATRA), a therapeutic mainstay for acute promyelocytic leukemia, is associated with off-target effects on skeletal development, including premature growth plate closure. However, the molecular mechanisms underlyi…
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