Current medicinal chemistry
Aspirin Downregulates PDE4D to Inhibit Malignant Progression of Osteosarcoma through the NF-κB/p65 Pathway.
Jinwu Wang, Yan Zhang, Zhuolun Li, Yiqin Li, Peng Zhou, Yao Xu, Long Chen, Houzhi Yang, Chao Zhang, Jinyan Feng, Guowen Wang
Published: 202610.2174/0109298673387686251015053130
Abstract
INTRODUCTION: Osteosarcoma is a highly aggressive cancer with a notably low five-year survival rate. Although aspirin has demonstrated potential in inhibiting the malignant progression of osteosarcoma, the underlying mechanisms remain unclear. METHOD…
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