Current medicinal chemistry
Identification of Novel Leads as Antitubercular Agents that Target Mtb-DHFR by using Virtual Screening.
Kalicharan Sharma, Divyanshi Thakur, Milendra Turkar, Mohammad Mumtaz Alam, Mohammad Shaquiquzzaman, Mymoona Akhter
Published: 202610.2174/0109298673384603250812175443
Abstract
INTRODUCTION: Drug-resistant tuberculosis (TB) is a global health concern, necessitating novel therapeutics. Dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis (Mtb-DHFR) is a promising target due to differences from human DHFR (h- DHFR),…
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