The Journal of toxicological sciencesHumansAutophagy-Related Protein-1 HomologCalcium-Calmodulin-Dependent Protein Kinase KinaseHep G2 CellsAMP-Activated Protein Kinases
Dihydropyrazine activates the CAMKK2-AMPK-ULK1 signaling pathway in human hepatoma HepG2 cells.
Madoka Sawai, Yuu Miyauchi, Hisao Kansui, Shinji Takechi
Published: 202510.2131/jts.50.577
Abstract
Dihydropyrazines (DHPs) are glycation intermediates produced by nonenzymatic glycation reactions in vivo and in foods. We previously reported that 3-hydro-2,2,5,6-tetramethylpyrazine (DHP-3) activates endoplasmic reticulum (ER) stress and inhibits au…
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