Zhongguo shi yan xue ye xue za zhiDecitabineHumansMyelodysplastic SyndromesEpigenesisGenetic
[The Epigenetic Regulation of Decitabine Resistance in TP53 -Mutated Myelodysplastic Syndromes: Integrated Analysis Based on RNA-seq and Methylomics].
Lan Zhang, Yu-Ye Ren, Wei Chen, Wen-Ya Hu, Chen-Xi Zhao, Li-Ping Su
Published: 202510.19746/j.cnki.issn.1009-2137.2025.06.019
Abstract
OBJECTIVE: To investigate the effects of TP53 genetic status (wild-type/mutated/null) on the drug resistance of decitabine (DAC) in myelodysplastic syndromes (MDS) and identify key resistance-associated genes. METHODS: Two myeloid cell lines with dis…
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