Bisphenol S impairs courtship, grooming, and locomotor behaviors in Drosophila melanogaster.

Bisphenol S (BPS), a common substitute for bisphenol A (BPA) in "BPA-free" products, is a potential developmental neurotoxicant. To investigate the developmental consequences of BPS exposure, we used Drosophila melanogaster as a model organism. Following exposure to BPS, we assessed three distinct behaviors: adult courtship, adult grooming, and larval locomotion. BPS exposure resulted in attenuated courtship activity, impaired grooming behavior, and some instances of altered larval locomotion. These findings support the hypothesis that developmental exposure to BPS, similar to BPA and structurally related analogs, can disrupt behavioral outcomes.