Revista espanola de enfermedades digestivas
Collagen expression downregulation and intestinal barrier impairment are associated with severe clinical phenotypes in very early-onset inflammatory bowel disease.
Hefang Wu, Hongwei Guo, Anding Zhang, Na Fan, Zeyu Liu, Yan Lin, Jiaren Zhou, Yaping Song, Siyuan Sun, Wenlun Zhong, Nini Zhang, Xiaochang Xue, Xun Jiang
Published: 202610.17235/reed.2026.11776/2025
Abstract
BACKGROUND: The global incidence of pediatric inflammatory bowel disease (IBD) is increasing steadily. Children with IBD under 6 years present unique clinical characteristics. OBJECTIVE: To compare very early-onset IBD (VEO-IBD) and late-onset IBD (L…
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