Journal of the American Society of Nephrology : JASN
Modulation of the APOM/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms.
Matthew Tolerico, Arianna Insenga, Judith Molina, Arianna Carrazco, Rachel Njeim, Alexis Sloan, Anthony Griswold, Makoto Kurano, Armando Mendez, Robin Nathans, Robin Bolek, Sandrine Ettou, Stephen Berasi, Alessia Fornoni, Sandra Merscher
Published: 202510.1681/ASN.0000000996
Abstract
BACKGROUND: Renal lipid dysmetabolism contributes to glomerular disease progression, including Alport Syndrome. We recently identified alterations in the apolipoprotein M/sphingosine-1-phosphate/sphingosine-1-phosphate receptor 4 signaling axis in gl…
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