Journal of the American Society of Nephrology : JASN
Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease.
Zemeng Wei, Jianlei Gu, Xin Tian, Chao Zhang, Hongyu Zhao, Stefan Somlo
Published: 202510.1681/ASN.0000000980
Abstract
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or polycystin-2 (PC2). The existence of a 'cilia-dependent cyst activation' (CDCA) pathway has been identified by showing that struct…
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