Journal of the American Society of Nephrology : JASN
Systemic Phosphate Elevations Induce FGF23 Production in Skeletal Muscle to Reduce Renal Phosphate Reabsorption in Mice.
Kylie Heitman, Qing Li, Abul Fajol, Matthew Denniff, Dungeng Peng, S Madison Thomas, Brian Czaya, Christopher Yanucil, David Westbrook, Syed Wasiuddin, Glenn C Rowe, Abolfazl Zarjou, Orlando M Gutierrez, Kenneth E White, Jorge L Gamboa
Published: 202510.1681/ASN.0000000963
Abstract
BACKGROUND: Fibroblast growth factor 23 (FGF23) is a hormone that reduces the renal reabsorption of phosphate in response to systemic phosphate elevations. In chronic kidney disease (CKD), serum levels of phosphate and FGF23 reach levels that can har…
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