A Passive Biomolecular Oxygen Diffusion Mechanism that Removes Oxygen from the Cell Nucleus as a Proposed Mechanism for the FLASH Effect by Radiochemical Oxygen Depletion and Transient Hypoxia of the Cell Nucleus.

Many mechanisms have been proposed to explain the normal tissue-sparing effect observed with FLASH radiation therapy. However, a satisfactory explanation has not been found. While the hypothesis of transient hypoxia through radiochemical oxygen deple…

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