Radiation researchAnimalsDNA Ligase ATPMiceDNA BreaksDouble-Stranded
Promoted Misrejoining of X-ray Radiation-induced DNA Double-Strand Breaks in Novel DNA Ligase IV-Deficient Mouse Cells.
Maiko Kawata, Kazunori Shiraishi, Izumi Satake, Yukako Hirato, Yusuke Yamashita, Hideki Kosako, Izumi Sasaki, Shinobu Tamura, Tuneyasu Kaisho, Seiji Kodama
Published: 202610.1667/RADE-25-00128
Abstract
DNA double-strand breaks (DSBs) are the most severe type of DNA damage in living organisms and are primarily repaired by two pathways: non-homologous end joining (NHEJ) and homologous recombination (HR). DNA ligase IV (LIG4) is essential for the fina…
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