Journal of Zhejiang University. Science. BPoly(ADP-ribose) Polymerase InhibitorsHumansDrug ResistanceNeoplasmNeoplasms
Future of PARP inhibitors in cancer treatment: overcoming resistance and enhancing efficacy with combination therapies.
Muhammad Shoaib, Zeeshan Ahmad Bhutta, Ahsan Javed, Muhammad Nabeel Amjad, Wenzhu Li, Kyung-Chul Choi, Wanxia Pu
Published: 202510.1631/jzus.B2400146
Abstract
Poly(ADP-ribose) polymerase (PARP) is a family of proteins that play a crucial role in diverse cellular processes, including DNA repair, cell death, and changes in chromatin structure. PARP inhibitors (PARPi) have been recognized as notable agents in…
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