The Journal of endocrinologyFemalePolycystic Ovary SyndromeAnimalsPregnancyMitochondria
Mitochondrial AR overactivation coupled with uterine decidual mitochondrial defects in PCOS-associated pregnancy loss.
Yuehui Zhang, Min Hu, Linus R Shao, Lingjing Lu, Jing Han, Tingting Guo, Meng Jiang, Yao Wu, Han Han, Peng Cui, Mats Brännström, Amanda Nancy Sferruzzi-Perri, Håkan Billig
Published: 202610.1530/JOE-25-0287
Abstract
Nuclear androgen receptor (AR) dysregulation characterizes polycystic ovary syndrome (PCOS) pathophysiology and contributes to mitochondrial dysfunction-related adverse pregnancy outcomes. However, ARs also localize to mitochondria in many cell types…
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