The Journal of neuroscience : the official journal of the Society for Neuroscience
Caudal Granular Insular Cortex to Somatosensory Cortex I: A critical pathway for the transition of acute to chronic pain.
Jayson B Ball, Maggie R Finch, Jeremy A Taylor, Zachariah Z Smith, Igor Rafael Correia Rocha, Suzanne M Green-Fulgham, Ethan B Rowe, Joseph M Dragavon, Connor J McNulty, Renee A Dreher, Imaad I Siddique, Gavin Davis, Andrew M Tan, Michael V Baratta, Daniel S Barth
Published: 202510.1523/JNEUROSCI.1306-25.2025
Abstract
Allodynia (perceiving touch as painful) is an enduring symptom of neuropathic pain. While acute pain is initiated by afferent signaling from the periphery to spinal cord, pain chronification recruits ongoing activity in supraspinal sites. One such si…
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