The Journal of neuroscience : the official journal of the Society for NeuroscienceAnimalsCalcium ChannelsT-TypeNeuralgiaSpinal Cord Injuries
The Increased Activity of CaV3.2 Channels Contributes to Nociceptors' Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury in Mice.
Kavindu Gunaratna, Huilin Liu, Jay Gupta, Erin Sipple, Michelino Puopolo
Published: 202610.1523/JNEUROSCI.1058-25.2025
Abstract
Following spinal cord injury (SCI), up to 60-70% of patients develop chronic neuropathic pain. SCI-induced neuropathic pain (SCI-NP) is often lifelong and therapeutically intractable, leading to a severe decline in quality of life and increased risk…
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