Mechanistic insights into Ras-catalyzed GTP hydrolysis: conformational dynamics, catalytic mechanisms, and emerging therapeutic strategies.

Ras is a key regulator of signal transduction in cells. Ras malfunction is associated with a huge variety of oncological diseases. It is turned off by hydrolysis of bound GTP, which is accelerated by GTPase-activating proteins (GAPs). This minireview…

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