Physiological reportsAnimalsHypertensionPulmonaryMiceKnockout
Inducible Ift88-deficient mice show features consistent with mild pulmonary hypertension.
Selina M Garcia, Benjamin J Lantz, Helen J Wagner, David T Jones, Rene Arechiga-Gonzalez, Tamara A Howard, Sana Gul, Terry H Wu, Thomas F Byrd, Olivia C Heath, Laura V Gonzalez Bosc
Published: 202610.14814/phy2.70749
Abstract
Intraflagellar transport protein 88 (IFT88) is essential for primary and motile cilia formation. In murine models and humans, Ift88 mutations contribute to renal cysts, epithelial proliferation and impaired immune responses. In mice, Ift88 knockout (…
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