Cellular and molecular biology (Noisy-le-Grand, France)HumansProtein Tyrosine PhosphataseNon-Receptor Type 11Hep G2 CellsCell Proliferation
Structure-based identification of liensinine as a natural allosteric SHP2 inhibitor with anti-proliferative activity in HepG2 cells.
Beom Su Seo, Dong Oh Moon
Published: 202510.14715/cmb/2025.71.12.5
Abstract
SHP2, encoded by the PTPN11 gene, is a non-receptor tyrosine phosphatase that plays a key role in oncogenic Ras/MAPK signaling. Aberrant SHP2 activity contributes to the progression of various cancers, including liver cancer. In this study, we used a…
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