Aging and disease
Histone H4 Lysine 12 Lactylation Promotes the Senescence of Alveolar Epithelial Type II Cells in Chronic Obstructive Pulmonary Disease by Modulating the CD38-NAD+ Signaling Pathway.
Chunxiao Yang, Qi Wang, Yuhan Xiong, Nan Ruan, Jun Yu, Yi Huang, Yu Liu, Cuntai Zhang, Weiwei Yu
Published: 202510.14336/AD.2025.0291
Abstract
In chronic obstructive pulmonary disease, the senescence of type II alveolar epithelial cells is a key driver of disease progression, severely impacting lung function and structure. Lactate accumulation, a common feature of chronic hypoxic conditions…
Preview only. Read the full abstract at the source