PloS onePhosphofructokinase-2AnimalsReceptorsCXCR4Myocardial Infarction
PFKFB3 exacerbates myocardial injury by accelerating CXCR4hi neutrophil mobilization after acute myocardial infarction.
Yingjia Xu, Min Xiao, Qin Zhu, Wutao Wang, Danrui Wang, Dadong Liu, Zongying Yu
Published: 202610.1371/journal.pone.0333657
Abstract
BACKGROUND: CXCR4hi neutrophil mobilization is a key cause of myocardial damage after acute myocardial infarction (AMI). 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key glycolytic enzyme, plays a crucial role in regulating neutr…
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