Yakugaku zasshi : Journal of the Pharmaceutical Society of JapanHumansAntimetabolitesAntineoplasticDihydrouracil Dehydrogenase (NADP)Fluorouracil
[Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations].
Eiji Hishinuma
Published: 202610.1248/yakushi.25-00124
Abstract
Fluoropyrimidine anticancer agents, exemplified by 5-fluorouracil (5-FU), induce severe adverse effects-such as myelosuppression, emesis, diarrhea, and hand-foot syndrome-in approximately 10-30% of patients. As such toxicities can result in delays or…
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