Chemical & pharmaceutical bulletinHumansStructure-Activity RelationshipImmunoglobulin GPeptidesImmunoglobulin Fc Fragments
Structure-Activity Relationship Study of Affinity Peptides for the Fc Site of Human Immunoglobulin G.
Kyohei Muguruma, Akane Fukuda, Hayate Shida, Rento Osawa, Soichiro Harigaya, Mayu Ito, Nana Sato, Aya Kuroda, Atsuki Kobayashi, Satoshi Kishimoto, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi
Published: 202510.1248/cpb.c25-00637
Abstract
Immunoglobulin G (IgG)-binding peptides have been widely used in medicinal chemistry, particularly in the preparation of homogeneous antibody-drug conjugates (ADCs). The dissociation constant (Kd) and kinetic parameters (kon and koff) are critical de…
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