Chemical & pharmaceutical bulletinAzidesHydrogen BondingMolecular Structure
Site-Selective Staudinger Conjugation of Aryl Azides Driven by Intramolecular Hydrogen Bonding.
Hiroki Tanimoto, Teruki Ishihara, Asuka Yotsu, Takenori Tomohiro
Published: 202510.1248/cpb.c25-00597
Abstract
Site-selective conjugation on aryl azides is hampered by a fundamental trade-off: electron-withdrawing groups that promote the reaction often preclude further functionalization, while versatile electron-donating groups suppress reactivity. We report…
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